Committee Membership Information

Study Title:

Review of EPA's draft paper State of the Science on Nonmonotonic Dose Response

Study Director:

Dr. David A. Savitz - (Chair)
Brown University

David A. Savitz (chair) is professor of epidemiology and obstetrics and gynecology at Brown University. He served as Carey C. Boshamer distinguished professor and chair of the Department of Epidemiology at the University of North Carolina School of Public Health until the end of 2005 and was Charles Bluhdorn professor of preventive medicine at Mount Sinai School of Medicine, 2006?2010. Dr. Savitz?s teaching is focused on epidemiologic methods, and he authored a book entitled Interpreting Epidemiologic Evidence. He has served as editor of the American Journal of Epidemiology and as a member of the Epidemiology and Disease Control-1 study section of NIH, and currently is an editor of Epidemiology. He was president of the Society for Epidemiologic Research and the Society for Pediatric and Perinatal Epidemiologic Research, and North American regional councilor for the International Epidemiological Association. Dr. Savitz?s primary research activities and interests are in reproductive, environmental, and cancer epidemiology. He has served on several IOM and NRC committees, most recently on the Committee on Contaminated Drinking Water at Camp Lejeune and the Committee on Obesity Prevention Policies for Young Children. He is a member of the IOM. Dr. Savitz received his Ph.D. in epidemiology from the University of Pittsburgh Graduate School of Public Health.

Dr. Russ B. Hauser
Harvard School of Public Health

Russ B. Hauser is the Frederick Lee Hisaw Professor of Reproductive Physiology and Professor of Environmental and Occupational Epidemiology in the Department of Environmental Health at the Harvard School of Public Health. Dr. Hauser also has an appointment at Harvard Medical School where he is Professor of Obstetrics, Gynecology and Reproductive Biology. Dr Hauser?s research focuses on the health risks of exposure to environmental chemicals that adversely affect human development and reproductive health. He is the principal investigator of two NIH funded studies on the health effects of environmental chemicals on infertility and pregnancy outcomes. He is also conducting an NIH funded study in Russia on the impact of environmental chemicals on children?s health. He has served on several NRC and IOM committees including the Committee on the Health Risks of Phthalates. Dr. Hauser is a member of two U.S. EPA Science Advisory Boards. He is serving on the U.S. Consumer Product Safety Commission?s Chronic Hazard Advisory Panel examining the effects of phthalates on children?s health. Dr. Hauser is an Advisory Board member of Environmental Health Perspectives, Journal of the National Institute of Environmental Health Sciences. Dr. Hauser has served as the Chair of the Environment and Reproduction Special Interest Group, American Society for Reproductive Medicine. He received an M.D. from Albert Einstein College of Medicine and an M.P.H. and Sc.D. from the Harvard School of Public Health where he completed a residency in Occupational Medicine. He is board certified in Occupational Medicine.

Dr. Heather B. Patisaul
North Carolina State University

Heather B. Patisaul is an associate professor in the Department of Biology at the North Carolina State University. Her research examines the steroid-dependent mechanisms through which sexually dimorphic behaviors and brain circuits arise, and she also explores the mechanisms by which sexually dimorphic systems and behaviors can be disrupted by environmental estrogens. Her laboratory is interested in the mechanisms by which exposure to environmental estrogens can advance puberty and impair fertility in females. She is a former investigator and post-doctoral researcher at the Hamner Institutes for Health Sciences (formerly known as CIIT). Dr. Patisaul served on the World Health Organization expert panel that assessed the risks of bisphenol A in 2010. Patisaul received her Ph.D. from Emory University in 2001.

Dr. Yiliang Zhu
University of South Florida

Yiliang Zhu is professor in the Department of Epidemiology and Biostatistics at the University of South Florida, College of Public Health. There he directs the Center for Collaborative Research. He is also professor of internal medicine, Morsani College of Medicine. His current research involves quantitative methodologies in health risk assessment, including physiologically based pharmacokinetic models, dose-response modeling, benchmark-dose methods, and uncertainty quantification. He also conducts research in health outcome and health system evaluation. Dr. Zhu is currently a Fulbright Research Fellow in China, establishing a 15-year cohort study on rural health and human development in northwest China. Dr. Zhu has served on several NRC committees, including those on Health Risk Assessment of Dioxins, Tetrachloroethylene, Formaldehyde, Science for EPA?s Future. He is currently serving on the Review of EPA?s IRIS Process. Dr. Zhu also served as a member of Department of Health and Human Services? Advisory Committee on Organ Transplantation and NIH?s study sections. He received a PhD in statistics from the University of Toronto.

Dr. Elizabeth N. Pearce
Boston University School of Medicine

Elizabeth N. Pearce is associate professor of medicine at Boston University School of Medicine. Her research interests include the sufficiency of dietary iodine in the U.S., thyroid function on pregnancy and lactation, thyroid effects of environmental perchlorate exposure and other potential endocrine disruptors, and the cardiovascular effects of subclinical thyroid dysfunction. She is a member of the board of directors for the American Thyroid Association (ATA) and the Management Council of the International Council for the Control of Iodine Deficiency Disorders Global Network, and serves on committees of the American Association of Clinical Endocrinology. She is an associate editor for thyroid research and has served as a member of the editorial boards of Thyroid, Endocrine Practice, and the Journal of Clinical Endocrinology and Metabolism. In 2011, Dr. Pearce received the Van Meter Lecture Award at the ATA?s 2011 annual meeting which recognizes outstanding contributions by a young researcher. She received her M.D. from Harvard Medical School, and did an internal medical residency at Beth Israel Deaconess Medical Center, and an Endocrinology Fellowship at Boston University School of Medicine. She received an M.Sc. in epidemiology from the Boston University School of Public Health.

Dr. Andrea Baccarrelli
Harvard School of Public Health

Andrea Baccarelli is the Mark and Catherine Winkler associate professor of environmental epigenetics in the Department of Environmental Health, Harvard School of Public Health. Dr. Baccarelli?s research focuses on epigenomics as a unique molecular substrate reflecting the impact of environmental exposures on human health. Epigenetic marks, including DNA methylation, histone modifications, and non-coding RNAs, modify chromatin structure and gene expression without changing the underlying DNA sequence. Dr. Baccarelli?s laboratory is investigating environmental epigenetics at different life-stages. Ongoing projects range from the investigation of the effects of in-utero exposures to toxic metals, second-hand smoking, and psychosocial stress on the methylome of human fetal tissues to the study of the influences of air pollution on non-coding miRNA in adult and elderly individuals. Epigenetic mechanisms are investigated in relation to fetal growth and perinatal outcomes, cardiovascular function, obesity, and neuro-cognition. Active studies include investigations in the U.S., Mexico, Canada, China, Italy, Belgium, Bulgaria, Poland, Thailand, Oman, and Bangladesh. Dr. Baccarelli received his M.D. from the University of Perugia, his M.P.H. from the University of Turin, and his Ph.D. from the University of Milan in Italy. He conducted post-doctoral research at the National Cancer Institute.

Dr. Amy H. Herring
The University of North Carolina at Chapel Hill

Amy H. Herring is professor of biostatistics and associate chair of the Department of Biostatistics, University of North Carolina, Chapel Hill . Research interests include longitudinal and multivariate data, hierarchical models, latent variables, Bayesian methods, reproductive and environmental epidemiology, and maternal and child health. Dr. Herring is a fellow of the American Statistical Association; was president of the International Biometric Society, Eastern North American Region (2010-2012); and currently serves on the Board of Directors for the International Society for Bayesian Analysis. She received the Mortimer Spiegelman Award for outstanding public health statistician under age 40 from the American Public Health Association in 2012. Dr. Herring received her Sc.D. in biostatistics from Harvard University.

Dr. Richard A. Corley
Pacific Northwest National Laboratory

Richard A. Corley is laboratory fellow in the systems toxicology group at the Pacific Northwest National Laboratory operated by Battelle for the U.S. Department of Energy. Dr. Corley specializes in the development of physiologically based pharmacokinetic models and multi-scale computational fluid-dynamics-based models of the respiratory system. He has published numerous peer-reviewed papers in toxicology, pharmacokinetic modeling, and cross-species dosimetry applications in human health risk assessments. Dr. Corley served on the NRC Committee to Review the Draft IRIS Assessment on Formaldehyde, the Standing Committee on Risk Analysis Issues and Reviews, and the Committee to Assess the Health Implications of Perchlorate. He received a Ph.D. in environmental toxicology and veterinary biosciences from the University of Illinois at Urbana-Champaign.

Dr. Tracey J. Woodruff
University of California, San Francisco

Tracey J. Woodruff is professor and director of the Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology, and Reproductive Sciences at the University of California, San Francisco and the Institute of Health Policy Studies, School of Medicine. Dr. Woodruff has extensive expertise in exposure assessment, environmental epidemiology, risk assessment and research translation. Her work focuses on early-life development and her research areas include evaluating prenatal exposures to environmental chemicals and related adverse pregnancy outcomes, and characterizing developmental risks. She is an associate editor and member of the advisory board for Environmental Health Perspectives. In 2012 she was appointed to the California Developmental and Reproductive Toxicant Identification Committee. She received her PhD in bioengineering from the University of California, Berkeley and San Francisco.

Dr. Robert E. Chapin
Pfizer Inc.

Robert E. Chapin is a senior research fellow with Pfizer, working in the Developmental and Reproductive Toxicology Center of Expertise. This center helps to interpret and weigh reproductive and developmental data for the organization, is involved in the development and application of in vitro models to screen compounds, and conducts mechanistic work for developmental and reproductive toxicology issues. Dr. Chapin is heavily involved in all these activities. Prior to coming to Pfizer in 2002, Dr. Chapin ran the reproductive toxicology laboratory for the National Toxicology Program at the National Institute of Environmental Health Sciences. Dr. Chapin received the NIH Director?s Award for Scientific Merit in 1995,and the Pfizer Achievement Award in 2010. Dr. Chapin received his Ph.D. in Pharmacology from the University of North Carolina, Chapel Hill.

Dr. George P. Daston
Procter & Gamble Company

George P. Daston is Victor Mills Society Research Fellow at the Procter & Gamble Company and an adjunct professor of pediatrics at University of Cincinnati. His current research efforts are in the areas of toxicogenomics and mechanistic toxicology, particularly in addressing how findings in these fields can improve risk assessment for chemicals and the development of non-animal alternatives. Dr. Daston has served as President of the Teratology Society, Councilor of the Society of Toxicology, on the USEPA?s Science Advisory Board and Board of Scientific Counselors, National Toxicology Program Board of Scientific Counselors, National Research Council?s Board of Environmental Studies and Toxicology, and National Children?s Study Advisory Committee. He has also served on several NRC committees and is currently a member of the NRC Committee on Use of Emerging Science for Environmental Health Decisions. In his advisory role at EPA, he oversaw the chartering and first five years of EPA?s acclaimed Computational Toxicology Program. He is Editor-in-Chief of Birth Defects Research: Developmental and Reproductive Toxicology. With scientists at the Humane Society of the US, Dr. Daston manages the AltTox website, which is devoted to the exchange of scientific information leading to the development of in vitro replacements for toxicity assessments. Dr. Daston has been awarded the Josef Warkany Lectureship and the Distinguished Service Award by the Teratology Society, the George H. Scott Award by the Toxicology Forum, the Society of Toxicology?s Best Paper of the Year Award, and is an elected Fellow of AAAS. Dr. Daston received his Ph.D. from the University of Miami and post-doctoral training at EPA?s laboratories in Research Triangle Park, NC.

Dr. Lauren Zeise
Office of Environmental Health Hazard Assessment California Environmental Protection Agency

Lauren Zeise is Deputy Director for Scientific Affairs for the California Environmental Protection Agency?s Office of Environmental Health Hazard Assessment (OEHHA). Dr. Zeise oversees the department?s scientific activities, which include the development of risk assessments, hazard evaluations, toxicity reviews, cumulative impacts analyses, frameworks and methodologies for assessing toxicity and cumulative impact, and the department?s activities in the California Environmental Contaminant Biomonitoring Program. Dr. Zeise was the 2008 recipient of the Society of Risk Analysis?s Outstanding Practitioner Award. She has served on advisory boards and committees of the Environmental Protection Agency, the Office of Technology Assessment, the World Health Organization, and the National Institute of Environmental Health Sciences. Dr. Zeise has served on numerous NRC and IOM committees. She is currently a member of the Committee on the Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee on Use of Emerging Science for Environmental Health Decisions. Dr. Zeise received a PhD from Harvard University.

Dr. Andreas Kortenkamp
Brunel University

Andreas Kortenkamp is professor for human toxicology at the Institute for the Environment, Brunel University. His research interests are in exploring environmental pollutants and their combined effects on endocrine diseases. In numerous publications he has investigated the effects of multi-component mixtures of chemicals that can disrupt hormone action. Dr. Kortenkamp has produced the State of the Art Report on Mixture Toxicology for the European Commission, Directorate General Environment. In 2012 he completed the State of the Art Assessment of Endocrine Disrupters for the European Commission. In addition, he was a member of the World Health Organization/United Nation Environmental Programme panel for evaluating the state of the science of endocrine disruption 2012. Dr. Kortenkamp has served on the NRC Committee on Health Risks of Phthalates and is currently a member of the US Consumer Health Advisory Panel on the assessment of phthalates. He earned his Ph.D. from Bremen University, Germany.