Animal models: Expert Reports

The division produces 60-70 reports per year. These reports are unique, authoritative expert evaluations. Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review. The experts who volunteer their time participating on study committees are vetted to make sure that the committee has the range of expertise needed to address the task, that they have a balance of perspectives, and to identify and eliminate members with conflicts of interest. All reports undergo a rigorous, independent peer review to assure that the statement of task has been addressed, that conclusions are adequately supported, and that all important issues raised by the reviewers are addressed. Thus, while the reports represent views of the committee, they also are endorsed by the Academy.

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Showing results 1 - 5 of 6

Animal Models for Assessing Countermeasures to Bioterrorism Agents (2011)

Transformational Medical Technologies, a component of the Department of Defense, funds the development of medical countermeasures to protect warfighters against potential biothreats such as emerging infectious agents and toxins and future genetically engineered biological weapons. Because these pathogens are potentially lethal or cause debilitating diseases in humans, it is ethically impermissible to test the effectiveness of medica... More >>

Toxicity Testing in the Twenty-first Century: A Vision and a Strategy (2007)

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The report finds that developing, improving, and validatin... More >>

Report in Brief

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents: Appropriate Use of Animal Models (2006)

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a stud... More >>

Toxicity Testing for Assessment of Environmental Agents: Interim Report (2005)

Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establis... More >>

Science, Medicine & Animals (2004)

The necessity for animal use in biomedical research is a hotly debated topic in classrooms throughout the country. Frequently teachers and students do not have access to balanced, factual material to foster an informed discussion on the topic. This colorful, 50-page booklet is designed to educate teenagers about the role of animal research in combating disease, past and present; the perspective of animal use within the whole spectrum o... More >>