Expert Report

Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review; while the reports represent views of the committee, they also are endorsed by the Academy. Learn more on our expert consensus reports.

In 1993, the National Research Council's Committee on Toxicology developed criteria and methods for EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) to develop community emergency exposure levels for extremely hazardous substances for the general population. A few years later, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC)--composed of members of EPA, DOD, other federal and state agencies, industry, academia, and other organizations--was established to identify, review, and interpret toxicologic and other scientific data to develop acute exposure guidelines (AEGLs) for high-priority, acutely toxic chemicals. Three levels--AEGL-1, AEGL-2, and AEGL-3 are developed for each of five exposure periods (10 min, 30 min, 1 hr, 4 hr, and 8 hr) and are distinguished by varying degrees of severity of toxic effects. This current report reviews the NAC reports for their scientific validity, completeness, and consistency with the NRC guideline reports developed in 1993 and 2001. This report is the fifth volume in the series and covers AEGLs for chlorine dioxide, chlorine trifluoride, cyclohexylamine, ethylenediamine, hydrofluoroether-7100, and tetranitromethane. It concludes that the AEGLs developed by NAC are scientifically valid and consistent with the NRC guideline reports. AEGLs are needed for a wide range of planning, response, and prevention applications. These values provide data critical to evacuation decisions and discussions between community leaders and industries as they seek ways to minimize the health impact should the chemical release occur. Some of the finalized AEGLs have been officially adopted by the Department of the Army, FEMA, and the Department of Transportation as the official levels for use by those agencies.

About this Report

Primary Board:

Board on Environmental Science and Toxicology

Other Report(s) in this series:

Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels (2005)
Thirteenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels (2005)
Fourteenth Interim Report of the Committee on Acute Exposure Guideline Levels (2006)
Acute Exposure Guidelines Levels for Selected Airborne Chemicals, Volume 6 (2008)
Sixteenth Interim Report of the Committee on Acute Exposure Guideline Levels (2009)
Seventeenth Interim Report of the Committee on Acute Exposure Guideline Levels (2010)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 8 (2009)
Eighteenth Interim Report of the Committee on Acute Exposure Guideline Levels (2010)
Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels: Part A (2011)
Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels: Part B (2011)
Twentieth Interim Report of the Committee on Acute Exposure Guideline Levels: Parts A and B (2011)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 (2011)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 11 (2012)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 12 (2012)
Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels: Parts A and B (2012)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 13 (2013)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 14 (2013)
Twenty-second Interim Report of the Committee on Acute Exposure Gudeline Levels (2013)
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 15 (2013)