Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision-Making: Proceedings of a Workshop -- in Brief (2018)Board on Life Sciences
Workshop Presentations and Video
Advances in the environmental health sciences -- from high-throughput cell-based in vitro studies to tissue chips to environment-wide association studies -- have led to new approaches for understanding the toxicity of chemicals in humans. These new approaches are faster, less expensive, and potentially more comparable to real-life human exposures than legacy animal toxicity testing approaches. However, many questions remain about whether -- and how -- to make the paradigm shift to using these new data streams as the basis for research, policy, and regulatory decisions.
This November 2017 workshop brought together scientists, policymakers, risk assessors, and regulators to explore key factors that influence how new science is incorporated into the decision making process. Drawing on expertise from the social sciences on issues such as the type and quantity of data that is "sufficient" for decision making, participants investigated case studies that illustrated examples of how the environmental health community has used these new approaches for decision making.